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Mortality and its predictors were calculated for the whole series, to achieve maximal statistical power.
This prevented the introduction of all the biases associated with dichotomization and results in maximal statistical power.
The latter approach reduces multiple testing concerns while retaining maximal statistical power, but requires complex permutation approaches (Peirce et al. 2008).
However, this 'enrichment' for psychopathological severity enabled us to test the association between the psychotic symptoms and functional outcome with maximal statistical power.
The log rank test and Cox regression models, the standard analyses in immunotherapy evaluation, have maximal statistical power under the proportional hazard assumption.
The grid point showing the maximal statistical power effect within the AI ROI was selected for stratification with respect to alpha power as described in the following.
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Also, despite a recent debate [ 87] as to which information-theory based measure provides the highest statistical power (maximal information coefficient or a related measure, mutual information), both measures clearly identify nonlinear trends that are missed by Pearson correlation.
In this latter eventuality, mean activity in the maximal hemisphere was taken, to increase statistical power.
This approach improved SKAT's statistical power, from 31%to45%5% at maximal sample size (see supplementary Table S3).
However, to achieve the best resolution and statistical power within this constraint, it is important to extract the maximal possible information from the genetic markers.
A total sample of 372 (124/grouprovideide 80% statistical power to detect differences ≥17.6% in pain and ≥9.6% in maximal compressive force at the 2-sided 0.0083 significance level with 80% retention (2-sample t-test, Nquery Advisor).
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