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The maximal cumulative radiation dose of 56 Gy (maximal single dose 1.8 Gy) was delivered to less than 20% of the optic chiasm.
Mitomycin-C shall be delivered at a dose of 10 mg/m (without exceeding a maximal single dose of 20 mg) via the IV route on day 1 +/- day 29, depending on local practice.
Maximal single dose and total dose were much lower than those predicted from the preclinical evaluation (before zoledronate administration) in the first three subjects because of markedly reduced expansion of V γ9V δ2 T cells from harvests undertaken after zoledronate administration.
A maximal single dose of 800 mg, on average 10 mg/kg bwt, was used in these studies to avoid the symptoms of paraesthesia, and is equivalent to the amount of β-alanine available from the ingestion of 150 g of chicken breast meat, assuming hydrolysis of the HCDs present.
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Therefore, 3 mg/kg was considered the maximal single recommended dose.
For comparison, the maximal recommended single dose in humans of IIM is 20 mg/kg body weight and a total of 1000 mg for FCM.
The maximal recommended single dose in humans of IIM is 20 mg/kg body weight and a total of 1000 mg for FCM.
Another study revealed that P-gp inhibition by CsA was maximal at a single dose of 10 mg kg−1 (Malingre et al, 2001b).
The doses corresponded to the maximal individual therapeutic single doses recommended for these analgesics.
However, the individual maximal rise following application of this single dose of vitamin D3 was variable, ranging from 1 to 47 ng/ml.
Previous studies have shown that hepatic CYP1A1, 1A2, and 1B1 protein levels are already maximal in rats 3 days after a single dose of TCDD (Santostefano et al. 1997).
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