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Progressive multi-focal or diffuse demyelination with axonal loss was observed pathologically in sciatic nerves in association with mononuclear cell infiltrates (F4/80+ macrophages > CD3+ T-lymphocytes > CD19+ B-lymphocytes), peaking at maximal severity.
However, migraineurs had less frequent headaches per month (10 vs. 22 episodes of TTH; P < 0.05) but headache took more time to reach the maximal severity among migraineurs (1.36 vs. 0.30 h in TTH patients; P < 0.05).
However, because of its sudden onset and its rapid ascent to maximal severity, features that may suggest a symptomatic headache, it is also the one most likely to be considered as a "warning signal".
A grade of functional severity in ARSACS varying from 0 to 2 (maximal severity) was then calculated.
Maximal severity of adverse events (AEs) was reported per NCI Common Terminology Criteria for Adverse Events (CTCAE), version 3.0.
Synovial cell proliferation and mononuclear cell infiltration were scored from 0 (normal) to 3 (maximal severity) (34).
Similar(44)
The maximal score (maximum severity of disease in individual mouse) of PBS -and berebrine-treated EAE mice were 3.43±0.22 and 2.10±0.22 respectively.
Per-patient maximal stenosis severity was defined by the maximum intraluminal stenosis in any of the coronary segments at the ≥50% stenosis threshold.
Three early time points (3, 6, and 10 days post-immunization [p.i.]), the time point of expected onset (day 15 p.i ., the time point for expected maximal clinical severity of arthritis (day 21 p.i ., the time point for transition to a chronic phase of disease (day 28 p.i ., and a late time point (day 38 p.i). were selected, and four animals per time point were sacrificed.
A sample of parents (n=20; 10 per site) purposefully chosen to ensure maximal variation in severity of child conditions, types of care needs as well as parental gender, socio-economic status, culture and educational level were invited to participate in one-time interviews examining their experiences of receiving care.
The continuous pain was dull, mild - moderate severity, and maximal in the retro-orbital and supraorbital areas.
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