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As stimulus frequency we used that of the respective maximal sensitivity in (a) (frequency of maximal linear response).
In contrast to the early PLR, the spectral response profiles for the steady-state equilibrium PLR and for the post-stimulus persistent responses are indistinguishable from each other and show maximal sensitivity in the blue region of the spectrum (approximately 460 480 nm; figure 2B, figure S1).
Although this approach guarantees maximal sensitivity in the case of unfiltered data, it is in general not feasible, and alignments have to be filtered stringently.
In the present study cost estimation was based on a full-costing accounting system and on the criteria of clinical Activity Based Costing (ABC) methods to obtain maximal sensitivity in the assessment of clinical activity variability.
Interestingly, in the kinetic expression f of the pyruvate kinase parameter n describing the influence of the feed-forward control (activation of the pyruvate kinase by glucose 6-phosphate) shows maximal sensitivity in both cases.
Data in parentheses are numbers used to calculate percentages To obtain 100% specificity and maximal sensitivity in malignant gland tumours by using the combination of PEW30, RPEW30 and PEW90 (Table 4), we obtained the threshold value criteria as follows: −70% > PEW30 < 36%, −30% > PEW30 < 19%, PEW90 > 12%, and 74% sensitivity was yielded (Fig. 1a e).
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Remarkably, after printing, the GMR sensor elements reveal up to 37% change of the electrical resistance in the magnetic field with a maximal sensitivity of 0.93 T−1 in a field of 130 mT. With this performance, the printed magnetoelectronics is comparable to reference samples prepared using standard thin film fabrication technology.
Conversely, the most informative value of q is half unity, which corresponds to the point of maximal sensitivity to variation in [Ab] (e.g., at which the second derivative of f in (4) and (5) is zero) in the estimation of q.
Second, the region of maximal sensitivity is located in the center of the sensitivity map corresponding well to a region of the LE map where the LE is negative and close to zero.
Additionally, using a cut-off for instability at ≥2/5 markers to define MSI results in maximal sensitivity and specificity for this assay, particularly for samples mutant for MSH6.
We used the point of maximal sensitivity with least compromise in specificity as the new optimal TLC cutoff point.
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Justyna Jupowicz-Kozak
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