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Truncation, however, significantly impairs maximal responses of the receptor mutants (ratios 0.6-0.8 0.6-0.8
The maximal responses of the tested compounds ranged between a 3.2-fold increase and a 7.7-fold increase (T – 6.4, DHT – 7.7, Mb – 7.1, R1881 – 3.2).
It was fund that the maximal responses of second curves were increased in the presence of either antagonist.
When IP accumulation was measured in sensory neuron cultures after treatment with ET-1 or BK, significant differences between maximal responses of the agonists were observed).
Inhibition of the positive control leukemia cell line NALM-6, and of osteosarcoma cell line U-2 OS with MK-2206 was dose-dependent, with IC50s of 0.38 μM and 2.5 μM, and maximal responses of 94% and 71%, respectively.
Baseline measurements of tissue resistance (Rt) and elastance (Et) were obtained for 5 min, and then the maximal responses of R and E were collected 10 min after a specific antigen challenge with OVA (0.1%) in the bath [ 26].
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Airway responsiveness was determined by investigating the maximal response of G, H, an RN upon intravenous methacholine (MCh) injection in incremental doses (0 (PBS), 0.03, 0.1, 0.3, 1, and 3 mg/kg).
However, decrease in maximal response of the T3 group was significantly greater than the saline group (P<0.01).
In the melanization bioassay, the constrained analog exceeded the efficacy (maximal response) of the natural PBAN1-33 by a factor of 2 (at 1 nmol).
Under voltage clamp conditions, monolayers responded to apical addition of ASC in a dose-dependent manner, with positive short circuit currents (ISC), ranging from 3 μatcm2 at 5 μM ASC to a maximal response of 27 μatcm200t 200 μM, and a half-maximal response at 40 μM.
Figure 5 shows the saturation or maximal response of the Ni-doped nanotube sensors to the hydrogen-containing atmosphere and air background at operating temperatures of 25°C, 100°C, and 200°C.
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