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However, similar to many large-field neurons in other species [ 3, 4], the motion direction that evokes maximal responses is not uniformly the same but varies in the different parts of the visual field.

In normal children the stimulus strength required to obtain maximal responses is <20 mA, but in patients with MLD the threshold was often markedly increased requiring stimulus strengths of 50 100 mA and prolonged duration above the usual 0.2 msec to ensure supramaximal stimulation.

The film thicknesses corresponding to the maximal responses are associated with the porous structures and the porosity of the thin films.

Maximal responses were observed 14 days after the boost.

Maximal responses were measured for the no-adaptor condition (16.7 & 10.7 nAm, for right and left hemisphere, respectively) and minimal responses for adaptor locations within the left hemifield (5.7 6.4 & 4.0 4.9 nAm).

Kinetic rate constants were approximated globally, maximal responses were fitted locally and bulk response was set to zero.

Maximal response in tumour Ktrans occurred at 26 h after starting the CYT997 infusion in patient 25, whereas in all other cases maximal responses were at 6 days.

Sites producing maximal responses were well-localized; microinjections 0.5 1.0 mm medial or lateral to these sites were typically ineffective or produced comparatively small responses at longer onset latencies.

Indeed, maximal responses were reached in hepatocytes after 4 15 days depending on genes, while less than 24 hours are necessary with endothelial cells.

Cell counts remained relatively low during the first two weeks of treatment and maximal responses were often reached after several weeks.

Under the conditions of those experiments, the rate at which PTPs open increases over the Ca concentration range of 10 500 μM, but maximal responses are still obtained with 30 μM free Ca in less than 10 s.