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The films with the higher porosity would lead to the higher maximal responses and the larger corresponding film-thicknesses, or vice versa.
Metabolic and haemodynamic changes were quantified by maximal responses and by calculation of areas under the concentration time profile (AUC).
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In sedated patients, starting intensity was set at 60 80 % of that resulting in maximal response and increased by 10%% every 3 min up to 100%%.
Full-field electroretinogram testing was normal for the right eye, with the exception of prolonged implicit time of the b-wave maximal response, and abnormal for the left eye, with reduced amplitudes of the isolated and maximal rod responses and a significantly prolonged 30 Hz cone flicker implicit time.
For cells that showed supersaturation (n = 13/81), we removed the data points that were below the maximal response for contrasts larger than the one evoking the maximal response and the fit was made on this reduced data set.
We then calculated the time of maximal response and the time needed for cells to return to basal levels (Table 1).
As shown in Figure 1A, exposure of UCB at a concentration of 1 µM for 24 h had no effect on the stimulus-response curve, maximal response, and fEPSP waveform.
The fitting of concentration response curves were calculated according to y = {ymax−ymin/1+(x/EC50)n}+ymin (where ymax = response in the absence of agonist, ymin = response remaining in presence of maximal agonist concentration, x = concentration, EC50 = concentration of agonist producing 50% of the maximal response and n = slope) with Kaleidagraph 3.5 software (Synergy Software, Reading, PA, USA).
The fitting of concentration response curves were calculated according to y = {ymax−ymin/1+ (x/EC50)n}+ ymin (where ymax = response in the absence of agonist, ymin = response remaining in presence of maximal agonist concentration, x = concentration, EC50 = concentration of agonist producing 50% of the maximal response and n = slope) with Kaleidagraph software (Abelbeck Software, USA).
Since the LA does not have a clear architecture like the hippocampus and theta burst stimulation (TBS) was not able to induce stable LA-LTP in aged mice, we adjusted the stimulus to elicit a field potential at 50% of the maximal response and used high frequency stimulation (HFS) to induce LA-LTP.
From rate functions filter types to AM tone complexes were defined as follows: The criterion for the classification of filter types was the number of crossings of the rate function with a line at 50% maximal response, and the location of these crossings relative to the BP.
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