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In experiments, maximal response was often obtained only when the stimuli fell on disparate parts of the two retinas; these cortical cells were obviously disparity detectors, in contrast to others that gave maximal response when the stimuli fell on strictly symmetrically related parts of the two retinas i.e., on corresponding points.
When examining the receptive fields of rabbit ganglion cells, investigators found some that gave a maximal response when a moving spot of light passed in a certain "preferred" direction, while they gave no response at all when the spot passed in the opposite direction; in fact, the spontaneous activity of the cell was usually inhibited by this movement in the "null" direction.
There was also a significant (P < 0.01, n = 5) reduction in the maximal response when the receptor coupled to the inhibitory G protein chimera.
However, compound 2 displayed a significant reduction in maximal response when coupled to the Gαi chimera that was not observed when BETP was used.
An ultrasensitive response of a signaling system is characterized by a low, or damped response up to a certain threshold of stimulus, followed by an abrupt increase towards maximal response when this threshold is exceeded [ 23, 26, 27, 50].
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APO866 had a marked protective effect on CIA observed in 3 independent experiments, with a maximal therapeutic response when administered at 10 mg/kg (Fig. 2a).
(B ) Scatter plot showing significant response of RS neurons to the 'best call', that is, maximal excitatory response when compared to the baseline firing rate (Wilcoxon signed rank test).
Maximal response is scored when the subject reaches the top of the vertical screen (10×10 cm), which usually takes about 5 s.
The compound 2-induced response was significantly (P < 0.01, n = 6) influenced by the G protein chimera present displaying a reduced maximal response (Table 4) when coupled to the inhibitory pathway.
Exogenous CCK, 30 IDU kg-1, stimulated a maximal pancreatic secretory response when given intravenously and caused hypertrophy and hyperplasia of the pancreas when given subcutaneously over a period of 6 weeks (pancreatic wet weight, mg per 100 g body weight, controls 295.6 +/- 61; CCK treated 466.4 +/- 77, P less than 0.001).
On confirmation of the diagnosis, patients were offered a multimodality treatment programme consisting of 4 6 courses of induction chemotherapy followed, when maximal response was achieved, by surgery.
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