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Airway responsiveness was determined by investigating the maximal response of G, H, an RN upon intravenous methacholine (MCh) injection in incremental doses (0 (PBS), 0.03, 0.1, 0.3, 1, and 3 mg/kg).
However, decrease in maximal response of the T3 group was significantly greater than the saline group (P<0.01).
In the melanization bioassay, the constrained analog exceeded the efficacy (maximal response) of the natural PBAN1-33 by a factor of 2 (at 1 nmol).
Under voltage clamp conditions, monolayers responded to apical addition of ASC in a dose-dependent manner, with positive short circuit currents (ISC), ranging from 3 μatcm2 at 5 μM ASC to a maximal response of 27 μatcm200t 200 μM, and a half-maximal response at 40 μM.
Figure 5 shows the saturation or maximal response of the Ni-doped nanotube sensors to the hydrogen-containing atmosphere and air background at operating temperatures of 25°C, 100°C, and 200°C.
In functional assays of non-competitive antagonists, depression of the maximal response of agonist dose-response curves, and in some cases, rightward shifts, is produced.
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Ri-TMS was performed and demonstrated clear delineation of individual areas of maximal MEP response for the m.
For robustness, we defined the latter as the smallest size that elicited >95% of the maximal response.
On the other hand, the magnitude of pancreatic bicarbonate response (about 50% of maximal response to secretin) suggests it might act by releasing secretin.
The regions of maximal response to cortical stimulation were directly compared to the calculated position of maximal MEP response by TMS.
Truncation, however, significantly impairs maximal responses of the receptor mutants (ratios 0.6-0.8 0.6-0.8
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