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Before recording, input/output curves were calculated to set the optimal stimulation intensity which was adjusted to 50% of the evoked maximal response amplitude.
A second and more interesting behavior was observed in all RBCs, specifically when the membrane potential was in the range of activation of Ih: taper occurred also at the low frequencies (Figure 3B, bottom two traces), resulting in a maximal response amplitude at an intermediate frequency.
The resulting traces revealed changes in cone-generated responses with a progressive decrease in maximal response amplitude and sensitivity.
Analysis of this scotopic ERG b-wave showed marked time-dependent changes in both maximal response amplitude and sensitivity (Table 2).
According to neurophysiological evidence (Allman et al. 1985), the surround motion (subscript i0) is modelled to reduce the maximal response amplitude of neurons responding to the target motion.
Second, a decreased amplitude could reflect a decrease in affinity for cGMP or a decrease in maximal response amplitude in the mutant channels.
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For each hemisphere and subject, data from the channel-pair with maximal response amplitudes was chosen for further analysis.
Threshold and maximal response amplitudes were measured.
Rmax,r and Rmax,c are maximal response amplitudes, and I0.5,r and I0.5,c are the half-maximal flash intensities.
Through genetic manipulations we observed graded alterations in the maximal response amplitudes, timing of response onset, and sensitivity of rod and cone ON-BCs, while testing the effect of these changes on mouse visual performance.
We analyzed neuronal responses in terms of maximal response strength (amplitude).
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