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Boronterol was at least eightfold more potent than salbutamol as a smooth muscle relaxant drug (judged by the EC50 values) and showed a similar maximal relaxant effect as isoproterenol.
In the absence of l-NAME, MB, or ODQ, the maximal relaxant effect was 94.0% ± 2.7%.
The maximal relaxant effect was 94.0% ± 2.7% and 49.4% ± 0.7% for endothelium-intact and endothelium-denuded aortic rings, respectively.
Comparison of the Rmax obtained in rat versus human pulmonary arteries indicates that both anaesthetics have similar or even greater maximal relaxant effect in human compared to rat tissues.
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The potency (pD2) and the maximum relaxant effect to acetylcholine were greater in 2K than in 2K-1C aortas.
Methyl-β-ciclodextrin reduced the pD2 in 2K and the maximum relaxant effect in both 2K and 2K-1C.
Experiments in which 10 μ M ACh induced a maximum relaxant effect of less than 40% were discarded.
Results: Spermine exerted a potent relaxant effect on all spontaneous and agonist-induced myometrial contractions, with mean maximal inhibition values between 62.8% ± 4.3% and 91.4% ± 1.8% and pD2 values between 2.66 ± 0.23 and 4.01 ± 0.20.
This study demonstrates in detail the relaxant effect of αCGRP on rat MCA.
Pretreatment of apigenin significantly potentiated the relaxant effect of acetylcholine on phenylephrine-induced contraction.
This study thus demonstrates the relaxant effect of αCGRP on rat MCA.
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CEO of Professional Science Editing for Scientists @ prosciediting.com