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Furthermore, the endogenous supply of IL-2 in mixed cultures is insufficient to attain the maximal protective effect over cell viability conferred by this cytokine.
As low as 2 μM of resveratrol demonstrated obvious protective effect, with the maximal protective effect observed at the concentrations among 5 to 20 μM.
Since 5-20 μM of resveratrol demonstrated the maximal protective effect on MG132-mediated cytotoxicity of K562 cells, we used 5 μM of resveratrol in the following experiments.
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The maximal protective effects were 92.7%, 97.9% and 52.0% for ectoin (0.1 mM), ERT (0.5 mM) and mannitol (1.5 mM), respectively, against visible light and 68.9%, 59.8% and 62.7% for ectoin (0.1 mM), ERT (0.5 mM) and mannitol (1.5 mM), respectively, against UVA/visible light.
The latter finding indicated that the maximal protective effects of HLA-C5'-C allele on HIV disease course might be evident when this allele is present in HLA-B*57-containing genotypes, and the data presented below affirm this possibility.
Maximal tissue destruction would perhaps have overridden its protective effect since no additional immunosuppressive therapy was employed.
In mixed (glial/neuronal) hippocampal cultured cells, treatment with the NO donor SNP (100 μM) resulted in cell damage and resveratrol (5 ± 25 μM) treatment increases cell survival, and this protective effect was significant at 5 μM and maximal at the highest (25 μM) concentration tested.
If Gln injection time is same with or post LPS application, maybe could not exactly evaluate the protective effect of Gln on vascular reactivity because Gln-induced maximal HSP expression dose not obtained.
APO866 had a marked protective effect on CIA observed in 3 independent experiments, with a maximal therapeutic response when administered at 10 mg/kg (Fig. 2a).
In agreement with our results overexpressing RAC3, its major protective effect should be found in tumoral cells, where its expression is maximal.
Long-term treatment with BC also triggered a protective effect on induction of CAs 15, 30 or 45 days after DEN treatment, which was maximal on structural aberrations followed by numerical and physiological types.
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