In the alignment of reads, a maximal of three mismatches was allowed within the whole read (aligner V mode).
The box plots reveal an increase in drug promiscuity rates over time, with a maximal rate of six targets per drug in 2000 and 24 targets per drug in interval >2012.
Further we made results robust against outliers by winsorizing the CARs (all three time windows) by a maximal deviation of three times standard deviation from mean.
For the calculation of unhashed Morgan fingerprints [45], each compound substructure in the dataset, with a maximal diameter of four bonds, was assigned to an unambiguous identifier.
For the calculation of keyed ECFP_6 fingerprints, each compound substructure, with a maximal diameter of three bonds, is treated as a compound feature.
The soundnails had a maximal length of five seconds and were extracted from special sound effect collections using audio processing and machine learning schemes.
As the effects of discretization errors are eliminated by employing a sufficiently large number of collocation points (≥ 20) for reactor axis discretization, maximal multiplicity of five steady states appears.
The Lyapunov exponent based diagram also reveals the spike adding transitions, and the corresponding bifurcation lines can be drawn where the 2nd Lyapunov exponent reaches the maximal value of zero.
SMT C1100 shows a maximal increase of four to five-fold compared to vehicle with an EC50 of 0.4 µM (Fig. 1A).
Compliance with treatment was defined as follows: maximal deviation of one measurement from the allocated frequency (e.g. 3 to 5 in the high group, 0 to 2 in the low group).
