Sentence examples for maximal observed concentration from inspiring English sources

Cmax, maximal observed concentration; EC50, concentration associated with half-maximal effect; Emax, maximum possible measured glucose infusion rate; R, correlation coefficient for the TK/TD model; T1/2, half-life; TK/TD, toxicokinetic/toxicodynamic.

First, AUC inf could be slightly underestimated due to the absence of any sample before 2.7 hours post-ingestion and between 2.7 and 10.5 hours, as the mean maximal observed concentration has been previously reported between 2.5 and 4.4 hours post-ingestion [ 29].

Decrease in plasma R- and S-methadone concentrations was linear and demonstrated a first-order pharmacokinetics (maximal observed concentrations 566 and 637 ng/ml, half-lives 16.1 and 13.2 hours, respectively).

The maximal observed drug concentration (Cmax) and time to maximal observed drug concentration (Tmax) were obtained directly from the experimental data.

The maximal observed plasma concentration of R, S-methadone was 1,204 ng/ml at 2.7 hours (Table 1).

In vitro metabolism studies using human liver microsomes showed apparent affinity constants (Km) regarding CYP-mediated EDDP formation far above the maximal observed methadone concentration in this patient [ 19], suggesting that saturation of methadone metabolism did not occur in our patient.

On ICU admission, the blood glucose was 5.3 (2.8 to 7.3) mmol/l, plasma potassium was 3.3 (3.0 to 3.8) mmol/l, plasma lactate 2.0 (1.7 to 2.8) mmol/l, and the maximal observed plasma insulin concentration was 197 (161 to 1,566) IU/ml.

In our overdosed patient, the maximal observed R, S-methadone concentration was approximately three times higher than the reported peak levels in patients treated with a daily therapeutic dosage of more than 80 mg [ 18].

Interestingly, the maximal observed (R,S -methadone plasma concentration (1204 ng/ml) in this case report is not,S -methadonethree times higher than plasmaevels in patients treated with a daily dosage in exconcentration (mean dose ± standard deviation: 1204± 82 mg/day, ng/ml09) [ 3].

The maximal observed catalytic rate for each reaction (FU/min) was measured and plotted against the respective inhibitor concentration.

The maximal observed experimental enhancement of 523 times is close to this value.