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IPA constructs networks that optimize for both interconnectivity and number of focus genes under the constraint of maximal network size.
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Here, I test the hypothesis of maximal fitness arising from minimized network size under the scenario of interspecific competition in a single patch.
The network size is maximal (1066 pixels) in neurons cultured at 2% oxygen, and decreases to 630 pixels in RSNs cultured at 5% oxygen and again to 321 pixels in neurons cultured in atmospheric oxygen.
Our results indicate that there is a state in which maximal mitochondrial function is achieved with minimal ROS production, maximal energy capacity and increased mitochondrial network size and the fraction of the cell occupied by mitochondria.
The solid lines show the relationship between the maximal genotype distance D max and metabolic network size N as predicted by the equation (1) ρ = 1 + m − N min N (1 + m ), Here, R SE is the number of reactions that are super-essential for a given environmental demand S. We had estimated this number in our previous analysis of minimal networks.
The answer is yes. Figure 3A shows that the maximal possible genotype distance D max between metabolic networks of the same size increases with metabolic network size N.
The space complexity is O((D++D−)(log snd(n))+2)) where n is the network size, snd(n) is the smallest integer that does not divide n and D+ and D− are the maximal out and in degree, respectively.
Network size.
Conformance to network size.
After that, the aggregated network evidence is transformed to a maximal network evidence using rule 9.
Two performance objectives, including maximal node coverage and maximal network capacity, are considered, respectively, in this study.
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