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The activation time was determined as the point of maximal negative slope and marked with a cursor.
Figure 2 D shows the differential of each trace, to demonstrate the maximal negative slope d V/d t, from which ATs and RTs were calculated.
The AT, determined as the point of initial maximal negative slope d V/d tmin of the initial negative deflection, was measured using Spike2 software.
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Off-line determinations of local activation times (LATs) at each recording site were related to timings of the first detected waveform in the recording array at which the waveforms showed their maximal negative slopes.
The measurements were defined using the median slope as described above and taking the maximum positive slope and the maximum negative slope.
The spike time vs. maximal conductance relationship could be well fitted by a negative slope monoexponential for each spike event.
Depolarization and hyperpolarization slope indicate the maximum positive slope during the depolarization and minimum negative slope during hyperpolarization phase of the spike.
Red: negative slope.
which has a negative slope in P-T space.
Considering the modulation slope, the shift introduced by the Doppler effect is added (negative slope) or subtracted (positive slope).
Hence, a normal habituation gave a negative slope value, while potentiation gave a positive slope.
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