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In our phase I study, the maximal mean decrease in levels of 5-methyl-2'-deoxycytidine in peripheral mononuclear cell DNA was 33% in patients receiving 45 mg m−2 decitabine vs 35% in patients receiving 90 mg m−2, indicating that 45 mg m−2 induced only marginally less demethylation (Appleton et al, 2007).
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The theoretical maximal mean HDL-C increase and LDL-C decrease relative to baseline were 177 and 44.1%, respectively.
The mean decrease of all patients was maximal on day 7 (mean decrease of 34.8±79.0 U ml−1; P=0.034), while on day 30 this was less impressive (a mean decrease of 26.2±76.8 U ml−1; P=0.083).
The model was able to track experimental trends with a maximal mean squared error of 11.77 %.
The estimated mean decrease was 7.3 (1.0) presses.
The average current amplitude of compound EPSCs necessary to trigger a spike at threshold level was maximal (mean = 3.3, s.e.m. = 0.04 nA; n = 10) for EPSCs with fast kinetics (τrise/τdecay 0.1/1 ms), and gradually decreased when the EPSCs became slower (Figure 3E).
At the MTD levels, the maximal mean change (±s.d).d
a Bonferroni test: * maximal mean value or no statistical difference from the maximal mean value; # minimal mean value or no statistical difference from the minimal mean value.
During phase I clinical studies in HCV/HIV-coinfected patients, DEB025 monotherapy (1200 mg BID) resulted in a mean maximal decrease in HCV viral load of −3.6 log10 IU/ml after 15 days of therapy [24].
There was a also a mean maximal decrease in pH of 0.02 (95%CI: 0.03 0.005)(r = 0.48; Pearson's, p = 0.007; Figure 4A) per 100 mg/kg increase in L-arginine dose, but there was no significant change in mean pH in the patients given 12 g (Figure 4B).
Mean nadir was 1.3 mm (SD ± 0.4 mm), corresponding with a mean maximal decrease in thickness of 32%% (95 % CI 27 37 %) for all patients combined.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com