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Maximal longevity of female (p = 0.0128 by Fisher's exact test), but not male Ames dwarf mice, was reduced by GH + T4 treatment.
The natural polyanion spermidine can extend the chronological and replicative life span in yeast and increase the median and maximal longevity of fruit flies and nematodes (C. elegans).
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These out-bred populations showed median longevity of 20 23 weeks and maximum longevity of 25 32 weeks.
The most intriguing finding was that the complete elimination of normal RasGrf1 increased both average and maximal longevity independent of a role in cancer.
Reduction of maximal longevity was detected only in females.
Life history traits (k-value, female fecundity and maximal longevity) were tested as potential determinants of parasite species richness.
Understanding how different methods of DR induce lifespan extension is pivotal for the identification of all the components of the gene network that orchestrates maximal longevity extension in response to nutrient deprivation.
Because of the allometric relationship with maximal fish size; female fecundity and maximal longevity were corrected for maximal fish size using residuals of log-transformed life trait versus log-transformed maximal fish size.
Data in this paper show that ATF4 levels, levels of proteins controlled by ATF4, and levels of three mRNAs regulated directly by ATF4 are elevated in liver of mice exposed to each of five interventions shown elsewhere to increase maximal longevity: the drugs acarbose and rapamycin, diets low in calories or methionine, or transient milk deprivation limited to the suckling period.
From a fundamental point of view, these results are strongly consistent with a relationship between species maximal longevity and mitochondrial mutation rate, in agreement with the mitochondrial theory of ageing.
Thus, the increase in maximal longevity in this model may be explained by the fact that two main theories of aging (the free radical and the IGF-I theories of aging) are at work in the RasGrf1 −/− mice.
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