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Conversely, small (~ 30 nm) LNP systems showed maximal liver accumulation yet still had minimal activity.
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In liver, accumulation of lipids contributes to the pathogenesis of non-alcoholic fatty liver disease and to insulin resistance.
Considerable liver accumulation was only observed for [177Lu]citrate and [177Lu]DOTA MBP 2.
Purification by preparative RP-HPLC resulted in similar spleen and liver accumulation.
These biochemical alterations became more intense as QDs liver accumulation gradually increased.
The new maximal liver function capacity test (LiMAx test) is a real-time method to investigate the liver function.
The LiMAx test determines the maximal liver function capacity based on a non-invasive breath test.
We analysed the maximal ET accumulation in other tissues at high dose (ET++) for 28 days and found that, like ET tissue distribution in control animals, the liver and whole blood remain as the highest reservoirs for ET accumulation (Fig. 3b).
a Maximal acetate accumulation and maximum specific growth rate measured in cultivations of xfpk expressing strains.
Furthermore, we localized the site of maximal PPARβ/δ accumulation in the skin by immunohistochemistry.
ICI172,780 was effective in preventing the 15 min maximal cAMP accumulation (Fig. 4a).
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