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Of interest is that even further improvement of B7-mediated signaling due to CTLA-4 blockade did not advance LCMV-specific CD8+ T cell expansion, suggesting that the observed higher expression of costimulatory molecules is at a maximal level with respect to stimulating T cells.

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In Figure 7 it is shown that the amount of BChl a produced increased with the substrate concentration under semiaerobic growth conditions and reached maximal levels with 6 or 8 mM malate.

In contrast, we observed rapid in vivo degranulation with maximal levels within 1 h after stimulation and with no significant increase in the extent of degranulation when the assay time was increased to 2 h.

The earliest sign of secondary metabolites from the phenylpropanoid pathway in our data consisted of tannins procyanidin B1 and procyanidin B2 and catechin monomers all showing maximal level in dates with an early ripening profile (Additional file 6), in accordance with the literature [ 8, 51].

In protein levels we detected maximal level in GII with the constant level of expression in G3.

The ideal immunisation schedule should aim at a maximal level of effectiveness with a minimum number of doses needed.

The induction of luciferase expression from pAd5-KRAB-Bi-Tet-On-Luciferase was both time-dependent and dose-dependent, with the maximal level of luciferase expression achieved with 2 μg Dox/ml after 40 h of induction.

The maximal level of inhibition achieved with the peptidomimetics was comparable to that of RGD-containing peptides, whereas no significant effects were apparent with an RGE-containing peptide.

In the LPS stimulated group, the mRNA expression of CfLec-1 was significantly (P<0.01) up-regulated, and it reached the maximal level (5.9-fold compared with blank group) at 12 h after challenge.

*Level 5 = final level; **Level 6 = maximal level (if needed); ●Capsules with active compound; ○ Capsules without active compound.

We found elevated levels of Gpm6B mRNA in all grades of breast cancer with maximal level in G3.

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