Each value represents the maximal interaction energy value V c, p) between property p and cage c as calculated according Eq. 1, optimized by rotating the molecule in the box and keeping the largest value.
Interestingly, CRGDK functionalized AuNPs resulted in maximal binding interaction between the CRGDK peptide and targeted Nrp-1 receptor overexpressed on MDA-MB-321 cell surface, which improved the delivery of therapeutic P12 peptide inside targeted cells.
Dimerization has been used by this flavoenzyme in evolution to achieve maximal activity, a tighter interaction between the protein moiety and the coenzyme, and higher thermal stability.
Another interesting observation is that, due to interaction between components, maximal component efficiency does not always imply maximal system efficiency.
The Asp282-Cys283 peptide bond gradually switched to the cis-conformation and became the dominant form at pH 6.2, during which maximal binding interaction occurred between the M-ficolin and GlcNAc.
Of these 10 docking poses, the best pose of OxA in OX1 was selected on the basis of the maximal number of interactions between SDM-validated key residues of OX2 and OxA responsible for OxA potency and efficacy.
The best pose of the receptor peptide complex was selected on the basis of the maximal number of interactions between SDM-validated key residues of the receptor and the peptide responsible for peptide potency and efficacy.
This resulted in the reduction of purmorphamine EC50 without a strong effect on its maximal induction, thus supporting a competitive interaction between 25 and 29 and purmorphamine.
There was a significant interaction between hypothyroid treatment and maximal COX activity, whereby hypothyroidism significantly increased COX activity in muscle of the warm-acclimated fish but had no effect on the cold-acclimated fish.
Off Central Chile, amino acid concentrations and ratios were both maximal around 100 m depth, probably reflecting the interaction between the primary productivity gradient and the presence of an oxygen minimum zone (OMZ) reducing the degradation of sedimentary organics.
