Maximal induction of c-fos and c-jun mRNA by EGF occurred within 30 min of treatment with 10 ng/ml EGF.
Activation of both activator protein-1 (AP-1; c-Jun/c-Fos) and nuclear factor-κB (NF-κB) pathways is necessary for maximal induction of the TF gene.
We conclude that in THP-1 cells and primary murine cells, SMAD4 signaling is required for maximal induction of endotoxin tolerance via modulation of SHIP1 and IRAK-M.
We found of all prime-boost combinations tested, an HIV-1 Env peptide subunit mucosal prime followed by systemic (intradermal) boosting with rMVA yielded the maximal induction of gamma interferon (IFN-gamma) spot-forming cells in the female genital tract and colon.
PGE2 release was measured before and after maximal induction of COX-2 mRNA (3 hours after stimulation with IL-1β).
A treatment time of 40 min was used, since this results in a maximal induction of DSBs by both drugs.
Our results show that the calcineurin/NFAT pathway and PKC-delta pathway are required for maximal induction of RCAN1.4.
These motifs appear to function synergistically to provide maximal induction of Cyp26a1 in response to AtRA [33], [34].
Both drugs enhanced the expression of Rad51 with the highest levels found at times of maximal induction of DNA damage.
Classical activation of lung macrophages and maximal induction of IL-23 and IL-17 required both TLR4 and TLR9.
The output from the naturally very dynamic CLN2 gene can be recapitulated by maximal induction of MET3pr for 15 minutes, with a cell-cell variability of about 25%.
