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Kinetics of maximal glucose use in diabetic or obese patients is markedly different from those in normal individuals because of post-receptor abnormalities or downregulation of insulin receptors as a consequence of the hyperinsulinaemia associated with over-eating [ 6].
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During the final three 20-min intervals, the mean glucose infusion rate was used to calculate maximal glucose uptake for each individual.
Taken together, these gene expression changes enable both maximal glucose uptake and a high efficiency of glucose utilisation.
This concept is supported by clinical studies both in animals and in humans, which have shown that the half-maximal concentration of insulin for antilipolysis is lower than for glucose use by peripheral tissues (35).
The maximal glucose disposal rate of 400 mg/m2 per minute (10 to 12 mg/kg per minute) was determined in normal volunteers using the euglycaemic hyperinsulinaemia glucose clamp technique [ 28, 31, 32].
Maximal glucose oxidase activity (28 U/ml/min) was achieved at the optimal fermentation conditions with 26.5 g/L DCM.
From these findings, we surmised that low residual xylan was critical in obtaining maximal glucose yields from saccharification.
HGI, admission glucose, mean morning glucose, mean glucose and maximal glucose were calculated for each patient.
Maximal glucose uptake for each individual was calculated from mean glucose infusion rate over the final three 20-min intervals.
Vm is maximal glucose flux together with Na+ (mole cm s−1).
The curvature parameter K M is the Michaelis constant that represents the blood glucose concentration at which the glucose uptake rate is half the maximal (glucose-saturated) rate.
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