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Exact(8)
In separate studies, contraction of TSM strips was assessed in vitro at optimal resting length and expressed as a function of maximal force generation to potassium chloride.
Similar to our findings, these mice retained normal maximal force generation.
Although normal maximal force generation was not impaired, it is likely that at physiological intracellular Ca2+ concentrations the observed Ca2+ desensitization leads to decreased force generation in vivo.
Similarly, the mass and force-generating capacity of female TA are unaffected by the absence of nNOSμ; therefore the differences between male and female force maximal force generation are likely due to differential impact on muscle mass.
It is known that isolated rat hearts subjected to ischemia exhibit decreased maximal force generation, as well as increased troponin I (TnI) degradation and sensitivity to Ca2+ [ 34].
The maximal force generation capacity of the muscle fibre preparations was normalized to their cross-sectional area (i.e. maximal active tension).
Similar(52)
This is an anticipated consequence of their patient status, but may represent a source of error if "true" force capacity of FM patients is masked by sub-maximal force generation in the calibration contractions due to, e.g., pain-associated inhibition.
Unique to tracheal strips from 1-wk-old animals, active force potentiated beyond the maximal force generated before oscillation.
The dependent variable was the maximal force generated during a unilateral isometric squat test.
TnC-extracted cardiac skinned fibers were reconstituted with the cTnC-A31S mutant, which increased Ca(2+) sensitivity with no effect on the maximal contractile force generation.
Muscle bundles were stretched until the fiber length was reached which provided maximal active force generation (100% Lmax).
More suggestions(13)
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