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The firing probability of each place cell increased when eSWRs occurred closer to the cell's place field centre, and the part of the place field area with maximal firing probability rapidly expanded over the course of eSWRs, reaching a maximum at the SWR peak.
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(F ) Scatter plots show the relationship between gridness score and the maximal firing rate during the simulation (left) and the probability of the maximal population-average firing rate during each theta cycle exceeding 300 Hz (right).
The mean firing rate of CNS neurons (∼4 Hz) [ 6, 21] is much less than the rate that would maximize information coding capacity (half the maximal firing frequency or around 200 Hz for a refractory period of 2.5 ms) [ 7].
The corresponding probability of bump formation (P(bumps)) and the maximal firing rate is indicated to the left and right, respectively.
The firing semantics of a globally synchronous system is characterised by maximal firing of input and output transitions.
Under control conditions the current required to induce a firing rate of 63% of the maximal firing rate was 0.65±0.06 nA (n = 20).
The maximal firing rate (Fmax) and the current that induced 63% of Fmax were extracted from each fit.
Maximal firing rate is indicated at the top right of each spatial firing plot.
Maximal firing rate is indicated to the top right of each spatial firing plot.
Gridness score and maximal firing rate of the firing field is indicated in the top left and right parts of each firing field, respectively.
(E ) Maximal firing rate of the four cells in response to square pulse current injection.
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