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The mean firing rate of CNS neurons (∼4 Hz) [ 6, 21] is much less than the rate that would maximize information coding capacity (half the maximal firing frequency or around 200 Hz for a refractory period of 2.5 ms) [ 7].
The current required to reach 63% of the maximal firing frequency increased from 0.53±0.06 nA to 0.76±0.18 nA (n = 7, p<0.02, paired t-test).
Following application of ACSF1 the F-I shifted to lower current values such that the current required to reach 63% of the maximal firing frequency fell significantly to 0.54±0.06 nA (Fig. 7A, n = 18, p<0.01, t-test, and see Fig. S3D for the F-I curve obtained at 35°C).
However, since the maximal firing rate increased, there was no significant change in the current required to reach 63% of the maximal firing frequency (from 0.55±0.06 nA (n = 14) under control conditions to 0.52±0.08 nA (n = 4) after application of 8 µM NMDA and 0.8 µM AMPA).
Small changes to conductances active around the resting membrane potential and participating in determining the spontaneous firing rate may cause large shifts in spontaneous firing rates without affecting the shape of the AP or the maximal firing frequency of the neuron.
Moreover, observation of amplitude changes after inactivity has suggested that fewer motor units were activated in disused muscle (Duchateau and Hainaut 1990), and maximal firing frequency of motor unit has been found to be decreased (Mayer et al. 1981).
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BIns belong to the group of cortical FS interneurons that are characterized by short duration (<0.5 ms) APs and high maximal firing frequencies (>200 Hz).
These neurons showed adaptation during repetitive firing and lower maximum firing frequencies (Fig. 5f).
Noisy limit cycles and quasi-cycles are mechanisms of emergent oscillations in neural networks, both of which allow the maximal firing rates of individual neurons to be lower than the network oscillation frequency.
The firing semantics of a globally synchronous system is characterised by maximal firing of input and output transitions.
The function f is referred to as the firing rate function, converting activity, u, to firing frequency, f ( u ), and h is a firing threshold.
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