Sentence examples for maximal feasible dose from inspiring English sources

These results demonstrate that, for future drug-discovery studies, it would be optimal to administer drug candidates at the maximal feasible dose.

No dose-limiting toxicities (DLTs) were observed in these phase I studies, in which the maximum tolerated dose (MTD) was not reached, and the maximal feasible dose and recommended phase II dose (RP2D) was 20 mg kg 1 every 3 or 4 weeks (Haluska et al, 2007; Lacy et al, 2008).

That is, considering the strength of marketed molecules in this space and a maximal feasible dose of 700 mg, a novel agent would need to exhibit at least a 50% point absolute improvement in PASI score over placebo to be considered for further development.

Administer the maximal feasible doses of test agents to enhance target identification.

Dose escalation proceeded without dose-limiting toxicities to a maximum feasible dose of 3 × 109 pfu.

The highest feasible dose was the maximal amount of extract that can be totally dissolved to yield the volume that a rat's stomach can hold [ 22].

28 For patients with nAA, the current standard treatment options include maximal feasible surgical resection followed by involved field, conformal RT similar to the dose schedule prescribed for nGBM (60 Gy in 30 fractions of 2 Gy each).

An optimal algorithm is obtained that minimizes the maximal feasible error.

To see this, first suppose the consumer burns the maximal feasible amount, xϵ.

The C-dose was the original working dose, while the E-dose was the highest feasible dose of CDTHD.

The detailed process of searching for the minimal and maximal feasible solutions is shown in Algorithm 1.