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In contrast, Sabourin and colleagues [ 51] found that Bcl-2 was expressed preferentially in lobular epithelial cells, with maximal expression at the mid-cycle period and a sharp decrease at the end of the menstrual cycle.
Lentivirus delivery from the bridge produced maximal expression at the implant and a gradient of expression rostrally and caudally.
Similar transient expression of P-selectin in vitro has been reported on murine endothelial cells with maximal expression at 3 h after stimulation with TNF-α [21].
Levels of α7-nAChR mRNA displayed a concentration-dependent increase with T14 treatment, with maximal expression at 100 nM.
The pipX gene in MED4 displayed maximal expression at sunset (Table S9) as did most of the N metabolism genes.
Conversely, for cytochrome c oxidase, which is used only in respiration, all subunits had maximal expression at sunset and minimal expression at sunrise (Figure 6 and Table S4).
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Cluster 1, consisting of 233 genes, exhibits a temporal profile characterized by upregulated gene expressions in salivary glands of C57BL/6.NOD- Aec1Aec2 mice between 8 and 16 weeks of age, with the vast majority of genes showing maximal expressions at 12 weeks of age.
α-Sarcoglycan reached half-maximal expression at day 4.3 [ 11], α1-syntrophin at day 6.0 [ 10], α-dystrobrevin-1 at day 6.6 [ 12], and nNOS at day 11.7 [ 13].
Nevertheless, the largest cluster of genes (cluster 1) identified differentially expressed genes upregulated with maximal expression levels at 12 to 16 weeks of age, or the time of detectable inflammation.
Initially, all data were expressed as a fraction of maximal expression, set at 1.0.
This experiment suggested an onset of pax10a expression at 25 h postfertilization (hpf) with the maximal expression level at 5 days postfertilization (dpf; fig. 6 A and supplementary fig. S1, Supplementary Material online).
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Justyna Jupowicz-Kozak
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