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Nevertheless, maximal enzyme induction was higher in the tranilast cultures, and we speculate this occurred because tranilast is less toxic than 3-MC.
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The production of MnP by native producers, as also observed in this study, is limited due to relatively low maximal enzyme activities, slow growth and the sensitivity of white-rot fungi towards shear forces, difficult induction strategies and low adaptivity to submerged fermentations.
The degree of enzyme induction can be characterized by the parameters such as EC50 (concentration causing half-maximal effect) and Emax (maximum effect) determined in in vitro studies.
Maximal enzyme activity was observed between pH 7 and pH 8.
It was observed that the polygalacturonase showed the maximal enzyme activity at pH 5.0.
This form of gene regulation is called enzyme induction.
Triton X-100 (0.2%) was added as a control for maximal enzyme release.
This strategy requires knowledge of maximal enzyme velocities (vmax).
The four analog mechanisms map to enzyme induction, enzyme elimination, drug metabolism, and enzyme-substrate binding.
This reflects liver enzyme induction in PCB-exposed pups.
Optimum conditions for mycelial growth and enzyme induction were determined.
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