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In addition, Sridhar et al. reported the anticonvulsant activity of hydrazones, the Schiff and Mannich bases of isatin, by the maximal electroshock method (MES) and metrazol-induced convulsions (MET).
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Anticonvulsant activity was done for grand mal and petit mal types of epilepsies by maximal electroshock (MES) and pentylenetetrazol (PTZ) induced convulsions methods respectively.
The target compounds were screened for their in vivo anticonvulsant activity following maximal electroshock (MES) and subcutaneous pentylene tetrazole (scPTZ) methods at a small test dose of 10 mg/kg.
In a study to investigate anticonvulsant activity of root bark extract of C. edulis, the median lethal dose (LD 50)) of its extract was determined using Lork's method and the anticonvulsant activity of the extract was assessed in pentylenetetrazole induced convulsion in mice and maximal electroshock test (MEST) in chicks, with benzodiazepine and phenytoin as standard drugs, respectively.
Table 3 Quantitative anticonvulsant data for mice using maximal electroshock test Sample number Maximal electroshock ED50 (mg/kg) 1 >200 2 >200 3 >200 Phenytoin standard 10.3 ± 0.6.
The suprathreshold tests employed were the maximal pentylenetetrazol test (MMT) and the maximal electroshock test (MES).
NAX 5055 was not active in the traditional maximal electroshock and subcutaneous pentylenetetrazol seizure models.
maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice.
Proconvulsant effects were seen, however, when the 'classic' diet was tested against maximal electroshock (MES) seizures.
Moreover, the most active compounds were tested against electrical induced convulsion using maximal electroshock (MES) models of seizures.
The anticonvulsant activity was evaluated in vivo by maximal electroshock (MES) test and subcutaneous pentylenetetrazole (scPTZ) test in mice.
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