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Source localization of alpha power, i.e. the difference in power between pause and observation intervals in the detection task, showed maximal effects in the left occipital gyrus, extending to the parieto-occipital sulcus dorsally (see Figure 3 left).
This difference also led to maximal effects in the t-map at inferior and superior electrodes.
From these data, concentrations of CNP that elicited maximal effects in vascular smooth muscle and endothelial cells (1 µM and 100 pM, respectively) were chosen for further experimentation.
Serotonin (30 μ m, a dose that produces maximal effects in cholinergic interneurons) induced reversible depolarizing effects (8.4 ± 3.6 mV) in 4/5 FSIs tested in the presence of TTX using conventional whole-cell recordings (Fig. 1C).
The doses of artemisinin derivatives used initially as monotherapy, and then subsequently in combination treatments (artemether at 1.6 mg/kg/dose in artemether-lumefantrine and dihydroartemisinin at 2.5 mg/kg/dose together with piperaquine), may not provide maximal effects in all patients.
In addition, LL-37 has recently been shown to bind IAV, without aggregating or affecting haemagglutination activity, and to have maximal effects in vitro when pre-incubated with virus (although delayed addition of peptide or treatment of the cells, with washing before infection also has some antiviral effects) [ 135].
Similar(53)
When given intravenously, the potent CGRP receptor antagonist olcegepant 2.5 most likely results in a maximal effect in the treatment of acute migraine [2].
The unique requirements of the mandibular ridge geometry and the intraoral environment are that traditional bone tissue engineering technologies, created primarily to fill bone defects, be modified and optimized for maximal effect in the protruding alveolar ridge site.
It has also found that the mechanical performance decreases with increase of the initial crack length for a given crack orientation, and that the initial crack orientation perpendicular to a tensile direction has a maximal effect in the reduction of the mechanical performance in this direction.
This may be due to diltiazem having reached maximal effect in vivo at the lowest dose.
However, these authors also pointed out that there was considerable pharmacokinetic and pharmacodynamic variance between individuals and that a dose of 4 mg/kg artesunate would be the minimum required to ensure a maximal effect in all individuals [7].
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