Suggestions(1)
Exact(2)
Maximal effects are usually achieved after 3 6 months (72) but may take even up to 1 year in individual cases (71).
While it is expected that drug effects will eventually saturate with exposure, linear models may be more prevalent for ECG changes, as maximal effects are often not achieved in safety studies where doses are selected based on margins to therapeutic exposure not to characterize the full concentration response relationship.
Similar(58)
Maximal effects were observed 5 10 min after 3.0 μg dose of melittin.
Maximal effects were found at minimal ND content of 0.25 wt%.
The dose-response curves of the three hormones were parallel, and their maximal effects were identical, suggesting a common mechanism of action.
Time-of-addition experiments revealed that maximal effects were achieved when glycyrrhizin was continuously present starting with a 1 h pre-incubation period (Figure 1D).
The maximal effects were observed with 10 µg/ml S100A14, and evident increase in cell proliferation was noted within 48 h following 10 µg/ml S100A14 treatment (Figures 1D and E).
Maximal effects were observed with 10 μ of HP-14.
Pouch fluid analysis: maximal effects were detected at 6 hours post LPS administration.
The maximal effects were found at parietal electrodes and bilaterally at inferior electrodes at the edge of the electrode array.
The maximal effects were found at parietal electrodes and at left inferior temporal and occipito-temporal electrodes at the edge of the channel array (Fig. 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com