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For subsequent coupling analysis, the voxel with maximal effect within each ROI was used (see Section D and E).
This activation of cell death was rapid, reaching maximal effect within 60 min. Paralleling our findings in studies of α-hemolysin-induced IL-1β secretion, the mutant α-hemolysin failed to elicit cell death at 1 hour (Fig. 5A), though at longer time points LDH release was observed with the mutant.
Carbogen breathing reached its maximal effect within ca. 10 min.
Pamidronate induced a profound fall in bone resorption with a maximal effect within the first month after therapy.
Cholecystokinin inhibits food intake with maximal effect within 30 min, while GLP-1 the GLP-1 thent incretin—also inhibits food intake, although it is not clear whether this occurs at physiological levels.
The inhibition of the ACh-induced current by menthol reached its maximal effect within 100 ms upon application, and the inhibition was 6.3 ± 4.0% (n = 6; P < 0.02, Figure 1C) and 10.1 ± 5.1% (n = 14; P < 0.001) for 100 and 200 μM, respectively.
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The data demonstrated that the effect of VPS34-IN1 in dispersing punctate endosomal localization of GFP 2×FYVEHrs was rapid with significant effects observed within 1 min (the earliest time-point that can be reliably analysed) and near maximal effects within 2 min.
We show that ITNs are more effective than IRS in reducing transmission and prevalence though IRS would achieve its maximal effects within 2 years while ITNs would need two mass distribution campaigns over several years to do so.
In addition, in a study on the in vitro simulation of human colonic microflora, it was noted that, contrary to inulin, the consumption of the four species of mushrooms stimulated the number of lactobacilli, with maximal effect depicted within the transverse segment of the colon.
For these 43 response components, the maximal effect of noise within the range of noise levels tested was quantified at the lowest SNR (highest test noise level) and this result is shown in Fig. 6B.
Background: The role of therapeutic drug monitoring (TDM) in the routine management of HIV-infected individuals is still unclear, largely due to a lack of basic data regarding specific drug concentrations and how they correlate with maximal effect and minimal toxicity within given populations.
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