Sentence examples for maximal effect that from inspiring English sources

In most cases, the sensitivity of the strain (or batch) to this product is difficult to predict, and preliminary tests are needed to provide information about the optimal dose/period to be applied, and about the maximal effect that can be obtained (Table 4.2.2.).

By calculating the percentage of the maximal effect that occurred after only 2 4 days, we established that the onset of the effect of incobotulinumtoxinA treatment is rapid, with 84% of the effect occurring by this time point.

A drug related PD property arises when a given dose yields concentrations that are much higher than the concentration resulting in half maximal effect such that the effect is prolonged for longer than would be expected given the declining plasma drug concentrations.

Alternatively, each domain may produce a maximal effect, such that no further benefits are possible.

As with S-phase cells, the maximal effect was that topotecan prevented all divisions from G1 cells, but half-maximal responses required a higher concentration of topotecan (0.96  μ M) than S-phase cells (0.14  μ M).

Criteria included reproducible IC50 values of less than 10 μM, saturating dose response curves with maximal percent effects that reached >90%, and a Hill coefficient that is close to 1 (a steep dose response curve can indicate compound aggregation).

Overall, this study underscores that stem cell therapy at optimal time frame is crucial to obtain maximal therapeutic effects that can restore functional deficits or stop the progression of AD.

Mutations in this region were found to increase the sensitivity of the enzyme to the DNA intercalating anti-tumour agents m-AMSA and ellipticine, but confer resistance to the non-intercalating agents etoposide, teniposide and merbarone, an effect that was maximal in the triple mutant.

As shown in Figure 1b, glutamate triggered a time-dependent increase in PFKFB3, an effect that was maximal (by ∼2.1-fold) after 6 h.

Collectively, these results could indicate that either (1) the dose of DPN used in our prior study was insufficient to produce a maximal effect, or (2) that ERβ plays a less critical mechanistic role than ERα in the defeminization of GnRH signaling pathways.

3E and 3F affirm an effect of Boc5 to dose-dependently slow gastric emptying in both db/db and wildtype mice, with a maximal effect similar to that of exenatide in the same protocol.