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In corresponding power analyses, we estimated where significant effects could be found under an assumption of maximal effect size given the observed spatial distribution of lesions.
This is done based on (a) the statistical parameter selected by the user, or (b) the maximal effect size.
Free flurbiprofen specifically decreased Aβ42 levels with a maximal effect size of approximately 70%, in good agreement with previous studies [ 17, 19].
The number of maternal effect targets, and their overall significance, are only slightly more modest than cis-regulatory effects, but nonetheless substantial, with approximately 1/3 as many genes involved, and maximal effect size of up to 3.5-fold difference or approximately 1/2 as large.
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This is basically in agreement with the meta-analysis on NbM and LC by Lyness et al. [ 93] where maximal effect sizes were clearly higher for the NbM than for LC.
While the study had 95% power to detect the maximal reported effect size, there is still potential for type II errors in such well-powered studies.
However, it should be noted that the effect size of maximal brain size on cognition is small: ICA accounts for only around 7% of the variance in g.
Our analysis, albeit severely limited by relying on only one study (Lovell et al. 2013), revealed actually an unfavorable −6.0%% net effect whole body vibration on maximal force in soccer players (effect size = −0.40).
Whole body vibration combined with exercise had an overall 10.2 % chronic effect on maximal voluntary force (14.6 %, weighted mean effect size = 0.44, 5 studies), leg power (10.7 %, weighted mean effect size = 0.42, 9 studies), flexibility (16.5 %, effect size = 0.57 to 0.61, 2 studies), and athletic performance (−1.2 %, weighted mean effect size = 0.45, 5 studies).
We felt it appropriate to censor the data from the three lines with the lowest plateaus, since the measurement of the maximal growth rate was imprecise because the effect size (growth) was smaller than the variance in microbe loads.
The effect size for acquisition memory was maximal for studies with a quality score of 4 (−4.05, 95 % CI: −8.02 to −0.08; Fig. 6a), and the effect size for retention memory was higher for studies with a quality score of 8 (5.95, 95 % CI: −0.63 to 12.59; Fig. 6b) than those with lower scores.
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