Sentence examples for maximal effect observed from inspiring English sources

Under the hypoxic condition (3% O2), treatment with Ca2+ increased the proliferation of the cells in a concentration-dependent manner, with a maximal effect observed at 1.8 mM Ca2+ (Fig. 1c).

Compared to controls, PD153035 treatment strikingly improved cardiac function, with a maximal effect observed at 1 nM.

The 6-fold increase of V394L GCase activity corresponded to ∼25% of WT levels, and was similar to the maximal effect observed in cultured skin fibroblasts from V394L/V394L or 4L C* mice (data not shown).

Endotoxin induced a massive increase in leukocyte accumulation in precapillary arterioles and postcapillary venules, with a maximal effect observed after 8 hours (Fig. 1).

This new phase one was deemed necessary as animal data suggested that repeated administration of OM-174 were needed to observe anti-tumor effect, with a maximal effect observed after 15 injections.

This difference was most noticeable when the TCR pMHC affinity decreased, with a maximal effect observed with the 5Y ligand, where PKI treatment increased the MFI by almost 4·5-fold.

Figure 1C shows that bafilomycin A was effective in raising endosomal pH at much lower concentration with maximal effects observed at a concentration of about 100 n M. Fluorescence micrographs show that doxorubicin was sequestered in a punctate pattern in the cytoplasm of both EMT-6 and MCF-7 cells (not shown) as well as being taken up into the nucleus, where it is known to target DNA.

As shown in the preceding study [12], PRP preparations exerted a biophasic effect with the maximal effects observed at 2.5 %, while in PRGF preparations, A-PRFext and CGFext stimulated cell proliferation in a dose-dependent manner (0.625 10 %).

The dose level for barusiban (150 μg kg-1 h-1) was determined according to maximal effects observed previously [ 16].

However, in the presence of the 5 mix and 13 mix, the maximal effects observed at saturating DHT concentrations rose far above the levels normally seen with the agonist on its own (i.e., "supramaximal" effects).

On the other hand, in HUVEC incubated in a medium containing 5.5 mmol/L D-glucose, the pro-inflammatory cytokine IL-1β enhanced the cell surface expression of both ICAM-1 and VCAM-1 in a concentration-dependent manner, with a sub-maximal effect observed at 5 ng/mL (Figures 1A-1B).