Sentence examples for maximal effect between from inspiring English sources
When administered orally (50 IU/kg) to diabetic rats, the nanoparticles can decrease rapidly the blood glucose level with a maximal effect between 1 and 8 h.
Proteolysis-inducing factor produced an increase in 'chymotrypsin-like' enzyme activity, proteasome 20S α subunits and E214k with a maximal effect between 2.1 and 10 n M, and this effect was completely attenuated in myotubes pretreated with PMA.
Effective concentrations (EC) were determined as drug doses with half maximal (EC50) or 80%EC8080) of the maximal effect between the upper plateau (no drug) and lower plateau (maximal effect of the drug).
Angiotensin II also stimulated protein breakdown with a similar dose response curve, and with a maximal effect between 1 and 2.5 μ M. Total protein degradation, induced by both Ang I and Ang II, was attenuated by the proteasome inhibitors lactacystin (5 μ M) and MG132 (10 μ M), suggesting that the effect was mediated through upregulation of the ubiquitin proteasome proteolytic pathway.
As shown in Figure 8A, 15(S -HETE induced elevated levelS -HETE- κB DNA binducedactivity in thelevatede nuclevelsafter a 30 min incubatiof, with a maximal effect between 156 and 234 n M. Increased nuclear accumulation of NF- κB was not seen after pretreatment with EPA.
Angiotensin I stimulated protein degradation with a parabolic dose response curve and with a maximal effect between 0.05 and 0.1 μ M. The effect was attenuated by coincubation with the angiotensin-converting enzyme (ACE) inhibitor imidaprilat, suggesting that angiotensin I stimulated protein degradation through conversion to Ang II.
Interestingly, the study did reveal that endostatin decreased tumour blood flow having maximal effects between 180 and 300 mg md.
Results from the MTT assay showed that cell growth of HaCaT cells increased with As treatment at low concentrations, with maximal effects between 0.5 and 1.0 μM, and then decreased as arsenite concentrations increased.
The maximal effect was observed between 30 and 90 minutes after injection, starting to revert thereafter.
An initial dose-response curve was performed, and a near maximal effect was seen between 50 and 100 nM DAPT (data not shown).
Maximal effects occurred between weeks 10 and 24 of therapy.
