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The sensitivity analysis of the maximal dynamic strain energy with respect to design variables in two scales, i.e., macro and micro scales, is presented.
The corresponding concurrent topology optimization model of macrostructure and microstructure is established, where the objective is to minimize the maximal dynamic strain energy of the macrostructure subject to volume constraints on the macromaterial distribution and phase materials.
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Maximum dynamic strain.
Specifically, local layer 2/3 networks should exhibit maximal dynamic range to process layer 4 inputs and maximize mutual information between patterns elicited in layer 4 and superficial layers.
Over-distension + low dynamic strain.
Over-distension + high dynamic strain.
Dynamic strain ranged from 100to18%8 % of global strain.
Dynamic strain at PEEP = Vt/(FRC + Vrec).
Dynamic strain at ZEEP = Vt/FRC.
Fig. 6 Dynamic strain and increase in lung weight.
Relationships between the dynamic strain and the lung weight increase.
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