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Specifically, local layer 2/3 networks should exhibit maximal dynamic range to process layer 4 inputs and maximize mutual information between patterns elicited in layer 4 and superficial layers.
To obtain standard curves with maximal dynamic range, baseline specimens were used as standards for vDNA-measurements.
The fact that the maximal dynamic range in our model corresponds to a power law response curve may be related with suggestions from theoretical models and experimental evidence [13], [40] [44] that optimal processing properties of sensory and neural systems in general are attaimed at or near a critical point of a phase transition.
The first region corresponds to the formation of Zn:HcZ9 and leads to a response that is ∼20% of the maximal dynamic range.
The second linear region correlates to the formation of Zn2:HcZ9 and yields a ratiometric response equal to ∼80% of maximal dynamic range.
This defines the maximal dynamic range of the method: a cargo moving from the cis-Golgi to the TGN will shift from a GM130/TGN46 ratio of about 80/20 (in the cis-Golgi) to a ratio of 20/80 (in the TGN).
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If it is out of the range, the corrupted pixel in the resulting noisy image will be saturated to the maximal or minimal value of the dynamic range, and that situation corresponds to the salt-and-pepper model.
The optimized assay included a multimerized TCF-binding site firefly luciferase reporter in human 293T cells with a fivefold dynamic range as determined by maximal stimulation with active N'Δβ-CATENIN and maximal repression with N'Δβ-CATENIN plus dnTCF (see Varnat et al, 2010) (Fig 1A).
These trends may be used to predict optimal processing conditions to suspend SWCNT with maximal start fluorescence for various wrappings, improving dynamic range and sensitivity.
The in silico investigation described in this work has shown that rod-rod coupling via gap junctions, in combination with appropriate values of the maximal rod Ih current conductance, enhances the dynamic range of scotopic vision in the vertebrate retina.
The 14 genes covered a large dynamic range of expression levels (maximal Ct = 37.85 (low relative level of expression); minimal Ct = 20.60 (high relative level of expression), see [ Additional file 4] for all array data and sample-matched QRT-PCR Ct values for the corresponding genes).
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