Sentence examples for maximal dose that from inspiring English sources

Trials of NMDA (N-methyl-D-aspartate) antagonists, however, have been troubled by psychotomimetic side effects that may well have meant that the maximal dose that could be tolerated was suboptimal in terms of neuroprotection.

To determine the virulence of the standard virus population (C-S8p260p3d), rescued by recombination between the two defective forms [5], [6], 21 mice were inoculated with 107 PFUs of C-S8p260p3d in the FP, the maximal dose that can be obtained with C-S8p260p3d.

The maximum tolerated dose (MTD) was defined as the maximal dose that causes neither greater than 15% of body weight loss nor mouse mortality within 2 weeks after administration.

Each batch of recombinant RANKL was tested in dose response studies and the minimal dose that promoted maximal osteoclast differentiation of WT marrow (typically 50 ng/ml) was used for all of the experiments with the exception of the dose-response studies reported here, where the maximum dose tested (100 ng/ml) was twice the dose used for differentiation studies.

Thus, in vivo trials were conducted on five healthy pig oesophaguses to determine the maximal thermal dose that will not induce a perforation of the oesophagus or surrounding tissues.

Extrapolating these results to the maximal insulin doses that were used in our study (1.7 U kg-1 day-1), it seems unlikely that free plasma insulin concentrations exceeded 500 850 pmol/l during treatment with insulin glargine.

When task performance after donepezil was determined as the individualized Best Dose, as a group, males responded maximally to less than half the dose that was maximal for females.

PIP prevalence also rose, largely due to increasing maximal dose PPI use that masked the reduction across most of the other PIP medicines.

Due to a low affinity of HI 6 with VR-inhibited pig AChE the oxime dose that causes maximal reactivation of VR-inhibited pig AChE is conspicuously higher compared to humans.

The difference between hematopoietic stem cell toxicity and antileukemic effects favors treatment with high doses of 5-AZA-CdR because the dose that causes maximal leukemic cell kill is not more toxic to resting hematopoietic stem cells.

Serotonin (30 μ m, a dose that produces maximal effects in cholinergic interneurons) induced reversible depolarizing effects (8.4 ± 3.6 mV) in 4/5 FSIs tested in the presence of TTX using conventional whole-cell recordings (Fig. 1C).