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Data in parentheses represent maximal dose, range (μg/minute for norepinephrine and μg/kg.min for dobutamine).
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PER-403 was the most sensitive of the NMC lines to γ-irradiation, with mean survival at the maximal dose ranging from 25% (PER-403) to 56% (PER-704).
The half-maximal doses ranged from 0.40 to 2.0 μg E2/kg bw/day in CD-1 and 0.6 to 1.05 μg E2/kg bw/day in C57Bl6 mice (Table 1).
The median maximal dose was 37 Gy (range, 18 62.5 Gy), with a median marginal tumor dose of 21 Gy (range, 14 25 Gy) at the 40 85% isodose line.
Moreover it is shown that the multi-pinhole SPECT method is able to identify differences in the range of 20% of the maximal uptake in the dose range between 950 kBq/g and 440 kBq/g employed in this study.
We employed doses of oxycodone and morphine causing the respective maximal antinociceptive effects within the dose range without showing side effects such as sedation (Nakamura et al., 2013), and tested the effects of blockade of Kir3.1 channels on the antinociceptive effects of these two opioids.
The maximal dose used in per participants ranged from 30 to 380 U without serious side effects, suggesting that 380 U for patients with FS might be a safety dose.
Five (12%95%% CI: 4.0 25.6) patients had a PR, which was achieved at a median maximal dose of 225 mg per day (range, 125 275 mg per day) (Table 3).
General health status and serum P levels were unaffected within the total dose range of Lantharenol® applied, including the maximal tolerated dose and beyond.
data processing tools allowed us to distinguish differences upwards from 20% of maximal tracer amount accumulated in the brains in the dose range between 440 kBq/g and 950 kBq/g.
The dose range equated to approximately 2-202-20%the maximal tolerated feed concentration determined in the dose escalation study.
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