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To find out the optimum maximal dosage of recombinant follicle stimulating hormone (rFSH) in microdose gonadotropin-releasing hormone analog (GnRH-a) flare cycles in poor responders.
Benzodiazepines, tricyclic antidepressants (except for Opipramol), and antipsychotics (expect for Quetiapine with maximal dosage of 50 mg) were excluded.
Medical therapy to reduce blood pressure was initiated with intravenous nitroglycerine and subsequently with maximal dosage of oral ramipril, amlodipine and hydrochlorothiazide.
Of the remaining 20 patients, 12 were indeed treated for 27 weeks according to the protocol, with 5 patients reaching the maximal dosage of 1.0 mg/kg/d.
Patients will be seen once or twice weekly to increase their dosage, until either a stable dosage or a maximal dosage of 800 μg/day is achieved.
In six patients, maximal dosage of norepinephrine was ≤ 0.1 μg/kg×min (group 1), in five patients between >0.1 and ≤ 0.2 μg/kg×min (group 2), and in seven patients >0.2 μg/kg×min (group 3).
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The dosage was reported to be equivalent to the maximal dosage for humans and was well tolerated by mice in a previous study [24].
This is a reasonable estimation of the maximal dosage after three months.
Body mass and application site will be considered for the calculation of the maximal dosage per patient.
Taken together, our study suggests that it might be important in the treatment of glioblastoma to apply temozolomide at the maximal dosage tolerated in the first cycle in order to avoid selection of resistant cells.
Introduction: Maximal dosage thresholds for catecholamine infusion were associated with almost 100%-fatality rate in patients presenting cardiovascular failure of non-toxic causes and mainly in case of sepsis.
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