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Analysis was carried out using all default settings as recommended by the software provider, except for the expected FDR, which was set to maximal detection of regulated transcripts with lowest amount of falsely called features (FDR 0%).
The device was designed with an emphasis on sensitivity to provide maximal detection of all positive margins.
Thus, real-time PCR allows for maximal detection of multiple viral and atypical infections in children with LRTI, with a negligible risk for false-positive results.
For maximal detection of pediatric TB, the optimal approach appears to be pairing Xpert with liquid culture (MGIT where available or MODS as an alternative).
For maximal detection of liver lesions, an additional dedicated series of acquisitions in a single bed-position can be readily appended to the whole-body acquisitions, including images with liver-specific contrast material [ 5].
For example, what is the optimal target or benchmark for the proportion of cases to be peer reviewed; a target of 100% ensures the maximal detection of medical error but may not be feasible in some centres, and other objectives (such as reduced variation in care and evaluation of treatment policies) can be achieved by reviewing a subset of cases.
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When the PD-L1-IgM + J-chain complexes were used at 6 μg/ml, signals for bound PD-L1-IgM fusion protein exceeded, at high PD-1-rCD4 concentrations, the maximal detection limit of the immunoassay system, visible in Fig. 2B as a plateau.
The MRM parameters of all analytes were optimized to achieve maximal detection sensitivity.
An optimal combination of compared features is used to construct an algorithm that provides maximal detection efficacy per unit hardware cost.
Maximal efficiency favours detection of very rare target molecules.
Doses for each compound were sub-maximal, allowing for detection of potential additive or synergistic pharmacological effects.
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