The articular step-off – the maximal depression or displacement of the articular surface in an axial direction on antero-posterior and lateral projections.
Each item is scored on a scale of 0 to 3, the total score ranging from 0 (no depression, no anxiety) to 21 (maximal depression, maximal anxiety).
The range is from 0 (no depression) to 27 (maximal depression).
In addition, low pH depresses maximal power in slow and fast skinned fibers: at low temperature (15°C) the fast fibers are more sensitive to a pH decrease, whereas at a temperature (30°C) close to physiological temperatures the depression of maximal power is greater in slow fibers [ 19].
In functional assays of non-competitive antagonists, depression of the maximal response of agonist dose-response curves, and in some cases, rightward shifts, is produced.
Inactivation of receptors normally results in a depression of the maximal response of agonist dose-response curves and a right shift in the curve occurs where there is a receptor reserve similar to non-competitive antagonists.
On the contrary, the antagonism of the two compounds at OX2R was surmountable with a right shift of the agonist concentration response curve without depression of the maximal effect.
Studies in rodent myocardium indicated that cTnT and cTnI phosphorylation influence Ca2+ sensitivity and were involved in the PKC-mediated depression of the maximal force generating capacity [ 8, 18, 32, 33].
The post-tetanic depression of inhibition was maximal 200 ms after the tetanus and typically lasted for about 2 s.
GSK1059865 and JNJ10397049 displayed a non-surmountable antagonism of Orexin-A with depression of the agonist maximal response at OX1R.
Paired pulse potentiation could be demonstrated only if the interpair interval corresponded to the period of maximal late depression and the interstimulus interval to the period of relative potentiation.
