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The maximal increase was 5.75 fold for Myosin head domain containing 1 and the maximal decrease was 4.92 fold for OCIA domain containing 1.
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Maximal decreases were obtained at an IL-1 concentration of 100 pg/ml.
Fasting blood glucose was also decreased in the two recent canagliflozin studies, but showed a slight progressive decrease after the maximal reduction was observed at weeks 4 [ 5] and 6 [ 6].
The maximal body weight decrease was achieved during the first year (>11% of initial body weight) in the orlistat-treated group compared to 6% decrease in the placebo-treated group.
The decrease was maximal at 5 days and recovery occurred by 15 days.
This decrease was near maximal by 12 to 16 weeks, no patients on atacicept had IgG levels below 3 g/l, and the rate of serious infections was not notably increased [ 11- 13].
Two hours after the injection the maximal (approximately 60%) blood glucose decrease was observed (from approximately 6 to approximately 2 mmol/L) which was followed by a glucose recovery, depending on the insulin dose.
The decrease was progressive and maximal at day 8, consistent with the array data.
Onset of weight decrease was defined as a drop of 5% of the mouse maximal weight.
The maximal decrease in activity was estimated at 49%, indicating that FTase could not completely be inhibited.
Maximal decrease of CXCR4 was recorded from 3 8 independent dose response experiments for each drug and cell line.
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