Maximal damage occurred earlier in the presence of the control strategy primarily due to the culling process, whereas the damage in the uncontrolled epidemic scenario was entirely due to death by AI. Figure 4B shows that there is an optimum value for the quarantine radius λ.
Cartilage damage in the tibial-femoral joint was scored using the OA score developed by Pritzker et al.[ 31], adapted by us for mice (from 0 = no damage, to 30 = maximal damage) [ 32].
In modular junctions with obvious macroscopic changes there was invariably a localised site of maximal damage where the taper had appeared to engage.
Each item was graded according to the following five-point scale: 0, minimal damage; 1, mild damage; 2, moderate damage; 3, severe damage; and 4, maximal damage [ 18].
Each item was graded according to a 5-point scale: 0, minimal (little) damage; 1, mild damage; 2, moderate damage; 3, severe damage; and 4, maximal damage.
Three observers blinded to the nature of the experiment scored lung injury from 0 (no damage) to 3 (maximal damage) according to three assessment categories: edema, alveolar congestion and infiltration of polymorphonuclear neutrophils (PMN) in the airspace or vessel walls.
In preliminary dose response experiments, a concentration of 2 μ M Dox was found to cause maximal damage while the prodrugs alone, up to 200 μ M, did not induce damage to the cells (data not shown).
The consistent pattern and location of maximal damage on the female taper is consistent with mechanical incompetence.
Changing the conservative assumption of a Gaussian beam profile, used in this analysis, to a more realistic parabolic profile reduce the maximal displacement damage in the window to about 53 dpa/ 5000 h.
In contrast, the administration of both compounds showed maximal effect in limiting the CIA damage in all parameters.
