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Bilateral addition of NH4+ caused a dose-dependent outward current (negative ISC), with a Km of 34 ± 8 mM and a maximal current response of 311 ± 47 µA cm− 2 (12 ± 2 µEq cm− 2 h− 1).
These studies were performed in rodent receptors where mCPBG has a maximal current response similar to that of 5-HT.
The maximal current response of the bioelectrodes modified by nAu (architecture CP-AMO-nAu-HRP-ferrocene) calculated from the calibration graph) is equal to 3.10 ± 0.05 μA which is 2.5 times higher compared to CP-AMO-HRP-ferrocene sensor architecture (1.23 ± 0.02 μA).
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We determined the concentrations of glutamate and glycine that can produce a half-maximal current response (EC50).
Electrode 9, overlaying left BA 6, was the same electrode at which we observed the maximal current increase in TMS-evoked responses after rTMS conditioning.
In the presence of this penicillin concentration, 30 μM flupirtine not only caused a small leftward shift in the concentration-response curve but also enhanced maximal current amplitudes.
Concentration-response data were fit to the equation: I = Imax/(1+ EC50/X n) where I represents the current response at a given concentration of odorant, X; Imax is the maximal response; EC50 is the concentration of odorant yielding a half maximal response; n is the apparent Hill coefficient.
Concentration-response data were fit to the equation: I = I max/(1+ EC 50/X) n) where I represents the current response at a given concentration of odorant, X; I max is the maximal response; EC 50 is the concentration of agonist yielding a half maximal response; n is the apparent Hill coefficient.
Concentration-inhibition data were fit to the equation: I = I max/(1+ (X/IC 50) n) where I represents the current response at a given concentration of inhibitor, X; I max is the maximal response in the absence of inhibitor; IC 50 is the concentration of inhibitor present that still allows a half maximal response from odorant; n is the apparent Hill coefficient.
Half maximal potentials (a measure of activation) were derived from the I-V relation from −109 mV to the peak of the current response.
The effects of applied potential on the current response of the composite-modified electrode toward glucose, the electroactive interference, and the stability were optimized to obtain the maximal sensitivity.
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