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After treatment of human temporal arteries by IL-1β, a pro-inflammatory cytokine, both maximal contraction and potency mediated by ETB receptors have been found to increase [ 19].
Vascular diameter, maximal contraction, and basal tone data were not normally distributed and were, therefore, analyzed using the Kruskal-Wallis test.
Hereafter, the RMS plots for both the maximal contraction and the relaxation measurement were visually controlled for 50 Hz interference, unilateral spikes, and abnormalities in the EMG signal.
BoNTA treatment resulted in significant improvement of line severity at both maximal contraction and rest, which is consistent with previous controlled clinical trials of this formulation [ 9].
Isometric force signals of the force frequency curve were analysed for maximal and total force and for maximal contraction and relaxation velocity.
Analysis of covariates indicated that at week 4, dose of BoNTA, line severity rating during maximal contraction and at resting position (both with baseline level subtracted), and subject-assessed line improvement were significantly (p < 0.001) related to subject satisfaction.
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After five familiarization repetitions, isokinetic strength was measured at 60°/s with 5 maximal contractions and at 180°/s with 15 maximal contractions.
Probably, in healthy subjects fatigue resistance reflects mainly the physiological ability of skeletal muscles to sustain maximal contractions, and is less linked to fatigue perception or motivation.
The subjects were carefully familiarized with the test procedures of voluntary force production during several warm-up contractions preceding the actual maximal contractions and were allowed to habituate to the electrical stimulation procedures during preliminary visits to the laboratory before definitive control measurements were taken.
After preincubation of Bdph (30~300 μM) or its vehicle for 20 min, histamine (10~30 μM) was added to reach a half-maximal contraction and then cumulatively added cromakalim (0.1~10 μM).
Second, after preincubation of Bdph (300 μM) or its vehicle for 20 min, histamine (10~30 μM) was added to reach a half-maximal contraction, and then Vrp (0.01~10 μM) or Nif (0.001~1 μM) was cumulatively added.
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