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We showed that LacCer presence leads to an increase in ERK 1/2 activation in a dose-dependent manner (Fig. 8) with a maximal concentration at 12.5 µM.
In contrast, the wild-type strain showed significant mortality at 24 h, with values of LD50 ∼ 100-fold lower than this maximal concentration at 48 h (Fig. 7 and Table 3 ).
At the root tip, auxin is distributed in a gradient-like fashion with a maximal concentration at the QC brought about by PIN-dependent transport following a reflux-loop design (Fig. 2B,C) (Blilou et al., 2005; Grieneisen et al., 2007; Petersson et al., 2009; Sabatini et al., 1999).
In experiments in which IL-1β was added at the same time as the source of IL-1Ra, similar end-point concentrations of IL-1Ra were found to provide corresponding inhibitory effects, despite the fact that the recombinant protein was at its maximal concentration at the time of IL-1 stimulation whereas that from the modified cells was zero.
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3, 38 This drug is well absorbed when administered orally, achieving maximal concentrations at 2.5 hours.
The cellular concentration of 6S RNA is not constant but shows a complex regulation in response to the growth phase [ 9, 10], reaching maximal concentrations at stationary growth.
At arterial pressures 95 mmHg and below, the maximal concentrations at x = 2 mm are approximately 500 mM, over a three-fold increase of the input concentration of 150 mM.
The maximal levels in plasma, kidney, spleen, lung, and heart are reached within 45 min, whereas in the case of liver a prolonged absorption phase was observed, with the maximal concentration reached at 8 h.
The mean maximal concentration (Cmax) at the RP2D level was 591±358 ng ml−1.
Further, the maximal concentration appears at a shorter time point, 48 min, in the case of AS alone, compared to the time point, 100 min, of the sum of AS, ASpOH and ASoOH.
After 7 nights of administration, the suvorexant blood concentration remained so substantial during the day that just before the next evening dose, the lowest daytime concentration on the 7 th day was more than half the maximal concentration achieved at T max during the first night.
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