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Markers of osteoclast function, for example, undergo near maximal changes within the first month following denosumab administration.
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Bar graphs show maximal changes in the mean arterial pressure (maximal ΔMAP) (upper panel) and heart rate (maximal ΔHR) (lower panel) in response to consumption of regular chow in SHR and WKY that received intracerebroventricular (i.c.v.) vehicle (n = 6) or 300 nmol TCS-OX2-29 (n = 6).
Bar graphs show maximal changes in the mean arterial pressure (maximal ΔMAP) (upper panel) and heart rate (maximal ΔHR) (lower panel) in response to consumption of sucrose agar in SHR and WKY that received intracerebroventricular (i.c.v.) vehicle (n = 6), 30 nmol TCS-OX2-29 (n = 6), or 300 nmol TCS-OX2-29 (n = 6).
Amplitudes of photoconversion were estimated under actinic light as maximal changes in optical density at 550 nm comparing to the dark-adapted state.
The maximal changes in Isc (∆Isc) after treatment with forskolin (10 µM), genistein (50 µM) or VX-770 (10 µM), were recorded.
The maximal changes scored at ∼0.7 nS.
Maximal changes were observed after six to nine hours.
Maximal changes occurred 24 hours after levosimendan infusion.
These defined the minimal and maximal changes, respectively.
He considers deeper-plane face-lifts "the gold standard," because they "last the longest and they can effect the maximal change," he said.
Two major differences became apparent as the time to reach maximal fluorescence and the magnitude of the maximal change were reduced compared to that of WT ABCD (Fig. 3B,C, yellow downward triangles).
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